重組人血清淀粉樣蛋白A 蛋白質(zhì)詳細(xì)說明
SAA是一種急性相蛋白并與血漿高密度脂蛋白(HDL)結(jié)合?，F(xiàn)在，研究把目光集中在炎性疾病急性反應(yīng)期間的SAA類型。與已被充分證實的急性相蛋白-CRP比較，SAA被用來檢驗其在急性炎性疾病的診斷中是否有任何優(yōu)點仍有待確定。
與CRP相仿，用以評估急性相反應(yīng)進(jìn)程。SAA是個靈敏的參數(shù)，它在炎性反應(yīng)大約8h后開始升高，且超過參考范圍上*早于CRP，然而CRP在正常人中的中位數(shù)值與參考范圍上限的差距，大約有10倍。在SAA中僅有5倍。輕微感染，例如，許多病毒感染，SAA升高要比CRP更為常見。在感染性疾病中，SAA的上升要高于CRP，因此SAA測定，尤其對“正常”與微小急性相反應(yīng)可提供更好的鑒別。通常約2/3感冒患者SAA升高，但少于1/2的患者相同表現(xiàn)CRP升高。在病毒感染病例中，SAA和CRP濃度升高見于腺病毒感染者。
分 子 量：14kDa
性 狀：Liquid
濃 度：0.8mg/ml
產(chǎn)品來源：基因工程表達(dá)
分 類：重組蛋白
純化方法：親和層析
產(chǎn)品應(yīng)用：Immunology research
保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹：Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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